diff --git a/mypy_django_plugin/transformers/fields.py b/mypy_django_plugin/transformers/fields.py
index a2f68fe..331a3f9 100644
--- a/mypy_django_plugin/transformers/fields.py
+++ b/mypy_django_plugin/transformers/fields.py
@@ -1,6 +1,6 @@
 from typing import Optional, Tuple, cast
 
-from django.db.models.fields import Field
+from django.db.models.fields import AutoField, Field
 from django.db.models.fields.related import RelatedField
 from mypy.nodes import AssignmentStmt, NameExpr, TypeInfo
 from mypy.plugin import FunctionContext
@@ -99,13 +99,26 @@ def fill_descriptor_types_for_related_field(ctx: FunctionContext, django_context
     )
 
 
-def get_field_descriptor_types(field_info: TypeInfo, is_nullable: bool) -> Tuple[MypyType, MypyType]:
-    set_type = helpers.get_private_descriptor_type(field_info, "_pyi_private_set_type", is_nullable=is_nullable)
-    get_type = helpers.get_private_descriptor_type(field_info, "_pyi_private_get_type", is_nullable=is_nullable)
+def get_field_descriptor_types(
+    field_info: TypeInfo, *, is_set_nullable: bool, is_get_nullable: bool
+) -> Tuple[MypyType, MypyType]:
+    set_type = helpers.get_private_descriptor_type(field_info, "_pyi_private_set_type", is_nullable=is_set_nullable)
+    get_type = helpers.get_private_descriptor_type(field_info, "_pyi_private_get_type", is_nullable=is_get_nullable)
     return set_type, get_type
 
 
-def set_descriptor_types_for_field(ctx: FunctionContext) -> Instance:
+def set_descriptor_types_for_field_callback(ctx: FunctionContext, django_context: DjangoContext) -> MypyType:
+    current_field = _get_current_field_from_assignment(ctx, django_context)
+    if current_field is not None:
+        if isinstance(current_field, AutoField):
+            return set_descriptor_types_for_field(ctx, is_set_nullable=True)
+
+    return set_descriptor_types_for_field(ctx)
+
+
+def set_descriptor_types_for_field(
+    ctx: FunctionContext, *, is_set_nullable: bool = False, is_get_nullable: bool = False
+) -> Instance:
     default_return_type = cast(Instance, ctx.default_return_type)
 
     is_nullable = False
@@ -113,7 +126,11 @@ def set_descriptor_types_for_field(ctx: FunctionContext) -> Instance:
     if null_expr is not None:
         is_nullable = helpers.parse_bool(null_expr) or False
 
-    set_type, get_type = get_field_descriptor_types(default_return_type.type, is_nullable)
+    set_type, get_type = get_field_descriptor_types(
+        default_return_type.type,
+        is_set_nullable=is_set_nullable or is_nullable,
+        is_get_nullable=is_get_nullable or is_nullable,
+    )
     return helpers.reparametrize_instance(default_return_type, [set_type, get_type])
 
 
@@ -148,4 +165,4 @@ def transform_into_proper_return_type(ctx: FunctionContext, django_context: Djan
     if default_return_type.type.has_base(fullnames.ARRAY_FIELD_FULLNAME):
         return determine_type_of_array_field(ctx, django_context)
 
-    return set_descriptor_types_for_field(ctx)
+    return set_descriptor_types_for_field_callback(ctx, django_context)
diff --git a/mypy_django_plugin/transformers/models.py b/mypy_django_plugin/transformers/models.py
index 14d09f3..00ad398 100644
--- a/mypy_django_plugin/transformers/models.py
+++ b/mypy_django_plugin/transformers/models.py
@@ -97,7 +97,9 @@ class AddDefaultPrimaryKey(ModelClassInitializer):
             auto_field_fullname = helpers.get_class_fullname(auto_field.__class__)
             auto_field_info = self.lookup_typeinfo_or_incomplete_defn_error(auto_field_fullname)
 
-            set_type, get_type = fields.get_field_descriptor_types(auto_field_info, is_nullable=False)
+            set_type, get_type = fields.get_field_descriptor_types(
+                auto_field_info, is_set_nullable=True, is_get_nullable=False
+            )
             self.add_new_node_to_model_class(auto_field.attname, Instance(auto_field_info, [set_type, get_type]))
 
 
@@ -131,7 +133,9 @@ class AddRelatedModelsId(ModelClassInitializer):
                         continue
 
                 is_nullable = self.django_context.get_field_nullability(field, None)
-                set_type, get_type = get_field_descriptor_types(field_info, is_nullable)
+                set_type, get_type = get_field_descriptor_types(
+                    field_info, is_set_nullable=is_nullable, is_get_nullable=is_nullable
+                )
                 self.add_new_node_to_model_class(field.attname, Instance(field_info, [set_type, get_type]))
 
 
diff --git a/tests/typecheck/fields/test_nullable.yml b/tests/typecheck/fields/test_nullable.yml
index e1fb2c6..f3ddaaa 100644
--- a/tests/typecheck/fields/test_nullable.yml
+++ b/tests/typecheck/fields/test_nullable.yml
@@ -1,3 +1,36 @@
+-   case: autofield_can_be_set_to_none
+    main: |
+        from myapp.models import MyModel, MyModelExplicitPK
+        m = MyModel()
+        m.id = 3
+        m.id = None
+        m2 = MyModel(id=None)
+        MyModel.objects.create(id=None)
+        MyModel.objects.all().update(id=None) # Should give an error since there's a not-null constraint
+
+        def foo(a: int) -> bool:
+          return True
+        m2 = MyModel()
+        foo(m2.id)
+
+        # At runtime, this would be an error, unless m.save() was called to populate the `id` field.
+        # but the plugin cannot catch this.
+        foo(m.id)
+
+        exp = MyModelExplicitPK()
+        exp.id = 3
+        exp.id = None
+    installed_apps:
+        - myapp
+    files:
+        -   path: myapp/__init__.py
+        -   path: myapp/models.py
+            content: |
+                from django.db import models
+                class MyModel(models.Model):
+                    pass
+                class MyModelExplicitPK(models.Model):
+                    id = models.AutoField(primary_key=True)
 -   case: nullable_field_with_strict_optional_true
     main: |
         from myapp.models import MyModel