diff --git a/mypy_django_plugin/django/context.py b/mypy_django_plugin/django/context.py
index 09c6e96..ba76298 100644
--- a/mypy_django_plugin/django/context.py
+++ b/mypy_django_plugin/django/context.py
@@ -198,7 +198,12 @@ class DjangoContext:
                 # it's generic, so cannot set specific model
                 field_name = field.name
                 gfk_info = helpers.lookup_class_typeinfo(api, field.__class__)
-                gfk_set_type = helpers.get_private_descriptor_type(gfk_info, "_pyi_private_set_type", is_nullable=True)
+                if gfk_info is None:
+                    gfk_set_type = AnyType(TypeOfAny.unannotated)
+                else:
+                    gfk_set_type = helpers.get_private_descriptor_type(
+                        gfk_info, "_pyi_private_set_type", is_nullable=True
+                    )
                 expected_types[field_name] = gfk_set_type
 
         return expected_types
diff --git a/tests/typecheck/fields/test_generic_foreign_key.yml b/tests/typecheck/fields/test_generic_foreign_key.yml
index d0979a8..b15690a 100644
--- a/tests/typecheck/fields/test_generic_foreign_key.yml
+++ b/tests/typecheck/fields/test_generic_foreign_key.yml
@@ -18,4 +18,27 @@
                 class User(models.Model):
                     pass
                 class Tag(models.Model):
-                    content_object = fields.GenericForeignKey()
\ No newline at end of file
+                    content_object = fields.GenericForeignKey()
+-   case: generic_foreign_key_subclass_could_point_to_any_model_and_is_always_optional
+    main: |
+        from myapp.models import Tag, User
+        myuser = User()
+        Tag(content_object=None)
+        Tag(content_object=myuser)
+        Tag.objects.create(content_object=None)
+        Tag.objects.create(content_object=myuser)
+        reveal_type(Tag().content_object)  # N: Revealed type is 'Union[Any, None]'
+    installed_apps:
+        - myapp
+    files:
+        -   path: myapp/__init__.py
+        -   path: myapp/models.py
+            content: |
+                from django.db import models
+                from django.contrib.contenttypes import fields
+                class User(models.Model):
+                    pass
+                class Tag(models.Model):
+                    content_object = fields.GenericForeignKey()
+                # Simulate a GenericForeignKey subclass without type infos.
+                Tag.content_object.__class__ = type('MyGenericForeignKey', (fields.GenericForeignKey,), {})