diff --git a/jedi/parser/utils.py b/jedi/parser/utils.py
index 296c66f5..f74e3e63 100644
--- a/jedi/parser/utils.py
+++ b/jedi/parser/utils.py
@@ -10,6 +10,7 @@ import pickle
 
 from jedi import settings
 from jedi import debug
+from jedi._compatibility import FileNotFoundError
 
 
 def underscore_memoization(func):
@@ -128,12 +129,15 @@ class ParserPickling(object):
             # the pickle file is outdated
             return None
 
-        with open(self._get_hashed_path(grammar, path), 'rb') as f:
-            try:
-                gc.disable()
-                parser_cache_item = pickle.load(f)
-            finally:
-                gc.enable()
+        try:
+            with open(self._get_hashed_path(grammar, path), 'rb') as f:
+                try:
+                    gc.disable()
+                    parser_cache_item = pickle.load(f)
+                finally:
+                    gc.enable()
+        except FileNotFoundError:
+            return None
 
         debug.dbg('pickle loaded: %s', path)
         parser_cache[path] = parser_cache_item
diff --git a/test/test_cache.py b/test/test_cache.py
index ba25cf84..56d3b804 100644
--- a/test/test_cache.py
+++ b/test/test_cache.py
@@ -3,6 +3,7 @@ Test all things related to the ``jedi.cache`` module.
 """
 
 import time
+from os import unlink
 
 import pytest
 
@@ -65,6 +66,37 @@ def test_modulepickling_delete_incompatible_cache():
     assert cached2 is None
 
 
+@pytest.mark.usefixtures("isolated_jedi_cache")
+def test_modulepickling_simulate_deleted_cache():
+    """
+    Tests loading from a cache file after it is deleted.
+    According to macOS `dev docs`__,
+
+        Note that the system may delete the Caches/ directory to free up disk
+        space, so your app must be able to re-create or download these files as
+        needed.
+
+    It is possible that other supported platforms treat cache files the same
+    way.
+
+    __ https://developer.apple.com/library/content/documentation/FileManagement/Conceptual/FileSystemProgrammingGuide/FileSystemOverview/FileSystemOverview.html
+    """
+    item = ParserCacheItem('fake parser')
+    path = 'fake path'
+
+    cache = ParserPicklingCls()
+    cache.version = 1
+    grammar = load_grammar()
+    cache.save_parser(grammar, path, item)
+    cached1 = load_stored_item(grammar, cache, path, item)
+    assert cached1 == item.parser
+
+    unlink(cache._get_hashed_path(grammar, path))
+
+    cached2 = load_stored_item(grammar, cache, path, item)
+    assert cached2 is None
+
+
 @pytest.mark.skipif('True', message='Currently the star import cache is not enabled.')
 def test_star_import_cache_duration():
     new = 0.01