diff --git a/jedi/evaluate/compiled/context.py b/jedi/evaluate/compiled/context.py
index 12e6e727..49cab814 100644
--- a/jedi/evaluate/compiled/context.py
+++ b/jedi/evaluate/compiled/context.py
@@ -127,7 +127,10 @@ class CompiledObject(Context):
             signature_params = self.access_handle.get_signature_params()
         except ValueError:  # Has no signature
             params_str, ret = self._parse_function_doc()
-            tokens = params_str.split(',')
+            if not params_str:
+                tokens = []
+            else:
+                tokens = params_str.split(',')
             if self.access_handle.ismethoddescriptor():
                 tokens.insert(0, 'self')
             for p in tokens:
diff --git a/test/test_api/test_call_signatures.py b/test/test_api/test_call_signatures.py
index 83ca628a..4ea04422 100644
--- a/test/test_api/test_call_signatures.py
+++ b/test/test_api/test_call_signatures.py
@@ -1,3 +1,4 @@
+import sys
 from textwrap import dedent
 import inspect
 
@@ -394,6 +395,7 @@ def test_keyword_argument_index(Script, environment):
     assert get(both + 'foo(a, b, c').index == 0
 
 
+@pytest.mark.skipif(sys.version_info[0] == 2, reason="Python 2 doesn't support __signature__")
 @pytest.mark.parametrize('code', ['foo', 'instance.foo'])
 def test_arg_defaults(Script, environment, code):
     def foo(arg="bla", arg1=1):