diff --git a/jedi/evaluate/compiled/__init__.py b/jedi/evaluate/compiled/__init__.py
index 480eb1a7..ddbd4165 100644
--- a/jedi/evaluate/compiled/__init__.py
+++ b/jedi/evaluate/compiled/__init__.py
@@ -323,7 +323,35 @@ def load_module(path, name):
         sys_path.insert(0, p)
 
     temp, sys.path = sys.path, sys_path
-    __import__(dotted_path)
+    try:
+        __import__(dotted_path)
+    except RuntimeError:
+        # RuntimeError: the PyQt4.QtCore and PyQt5.QtCore modules both wrap
+        # the QObject class
+        if 'PySide' in dotted_path or 'PyQt4' in dotted_path:
+            original_path = dotted_path
+            dotted_path = dotted_path.replace('PySide', 'PyQt5')
+            dotted_path = dotted_path.replace('PyQt4', 'PyQt5')
+            if 'QtGui' in dotted_path:
+                # special case, we need to merge QtGui and QtWidgets modules:
+                # PyQt4.QtGui (or PySide.QtGui) = PyQt5.QtGui + PyQt5.QtWidgets
+                __import__(dotted_path)
+                # get PyQt5.QtGui
+                qt_gui_module = sys.modules[dotted_path]
+                # get PyQt5.QtWidgets
+                dotted_path = dotted_path.replace('QtGui', 'QtWidgets')
+                __import__(dotted_path)
+                module_widgets = sys.modules[dotted_path]
+                # merge modules into PySide.QtGui or PyQt4.QtGui
+                qt_gui_module.__dict__.update(module_widgets.__dict__)
+                sys.modules[original_path] = qt_gui_module
+                return CompiledObject(qt_gui_module)
+        else:
+            dotted_path = dotted_path.replace('PyQt5', 'PyQt4')
+            if 'QtWidgets' in dotted_path:
+                # PyQt4.QtWidgets does not exists but all names can be found
+                # in QtGui
+                dotted_path = dotted_path.replace('QtWidgets', 'QtGui')
     # Just access the cache after import, because of #59 as well as the very
     # complicated import structure of Python.
     module = sys.modules[dotted_path]