diff --git a/jedi/api/refactoring.py b/jedi/api/refactoring.py
index de79a995..4ac0b2aa 100644
--- a/jedi/api/refactoring.py
+++ b/jedi/api/refactoring.py
@@ -134,15 +134,15 @@ def inline(grammar, names):
     if not names:
         raise RefactoringError("There is no name under the cursor")
     if any(n.api_type == 'module' for n in names):
-        raise RefactoringError("Cannot inline imports or modules.")
+        raise RefactoringError("Cannot inline imports or modules")
     if any(n.tree_name is None for n in names):
-        raise RefactoringError("Cannot inline builtins.")
+        raise RefactoringError("Cannot inline builtins/extensions")
 
     definitions = [n for n in names if n.tree_name.is_definition()]
     if len(definitions) == 0:
-        raise RefactoringError("No definition found to inline.")
+        raise RefactoringError("No definition found to inline")
     if len(definitions) > 1:
-        raise RefactoringError("Cannot inline a name with multiple definitions.")
+        raise RefactoringError("Cannot inline a name with multiple definitions")
 
     tree_name = definitions[0].tree_name
 
@@ -156,6 +156,19 @@ def inline(grammar, names):
 
     if len(expr_stmt.get_defined_names(include_setitem=True)) > 1:
         raise RefactoringError("Cannot inline a statement with multiple definitions")
+    first_child = expr_stmt.children[1]
+    if first_child.type == 'annassign' and len(first_child.children) == 4:
+        first_child = first_child.children[2]
+    if first_child != '=':
+        if first_child.type == 'annassign':
+            raise RefactoringError(
+                'Cannot inline a statement that is defined by an annotation'
+            )
+        else:
+            raise RefactoringError(
+                'Cannot inline a statement with "%s"'
+                % first_child.get_code(include_prefix=False)
+            )
 
     rhs = expr_stmt.get_rhs()
     replace_code = rhs.get_code(include_prefix=False)
diff --git a/test/refactor/inline.py b/test/refactor/inline.py
index 31344656..18d43894 100644
--- a/test/refactor/inline.py
+++ b/test/refactor/inline.py
@@ -1,10 +1,70 @@
-# -------------------------------------------------- multi-equal
+# -------------------------------------------------- no-name-error
+#? 0 error
+1
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+There is no name under the cursor
+# -------------------------------------------------- multi-equal-error
 def test():
     #? 4 error
     a = b = 3
     return test(100, a)
 # ++++++++++++++++++++++++++++++++++++++++++++++++++
 Cannot inline a statement with multiple definitions
+# -------------------------------------------------- no-definition-error
+#? 5 error
+test(a)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+No definition found to inline
+# -------------------------------------------------- multi-names-error
+#? 0 error
+a, b[1] = 3
+test(a)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline a statement with multiple definitions
+# -------------------------------------------------- addition-error
+#? 0 error
+a = 2
+a += 3
+test(a)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline a name with multiple definitions
+# -------------------------------------------------- only-addition-error
+#? 0 error
+a += 3
+test(a)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline a statement with "+="
+# -------------------------------------------------- with-annotation
+foobarb: int = 1
+#? 5
+test(foobarb)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+--- /home/dave/source/jedi/test/refactor/inline.py
++++ /home/dave/source/jedi/test/refactor/inline.py
+@@ -1,4 +1,4 @@
+-foobarb: int = 1
++
+ #? 5
+-test(foobarb)
++test(1)
+# -------------------------------------------------- only-annotation-error
+a: int
+#? 5 error
+test(a)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline a statement that is defined by an annotation
+# -------------------------------------------------- builtin
+import math
+#? 7 error
+math.cos
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline builtins/extensions
+# -------------------------------------------------- module
+from import_tree import some_mod
+#? 11 error
+test(some_mod)
+# ++++++++++++++++++++++++++++++++++++++++++++++++++
+Cannot inline imports or modules
 # -------------------------------------------------- simple
 def test():
     #? 4