diff --git a/.flake8 b/.flake8
index 1746f3c0f..73fbcafa9 100644
--- a/.flake8
+++ b/.flake8
@@ -18,11 +18,9 @@ ignore = F401, F811, E127, E128, E301, E302, E305, E501, E701, E704
 
 # Errors that we need to fix before enabling flake8 by default:
 #   921 F821 undefined name
-#    48 E225 missing whitespace around operator
 #    28 E116 unexpected indentation (comment)
 #    26 F403 from * import used
 #    14 E251 unexpected spaces around keyword argument '='
-#    14 E203 whitespace before
 #     8 B006 mutable argument defaults
 #     7 E999 invalid syntax
 #     7 E111 indentation is not a multiple of four
@@ -31,4 +29,3 @@ ignore = F401, F811, E127, E128, E301, E302, E305, E501, E701, E704
 #     4 E114 indentation is not a multiple of four
 #     3 E303 too many blank lines
 #     2 B303 __metaclass__ use on Python 3
-#     1 E202 whitespace before )
diff --git a/stdlib/2/inspect.pyi b/stdlib/2/inspect.pyi
index 138efb483..e86da66ba 100644
--- a/stdlib/2/inspect.pyi
+++ b/stdlib/2/inspect.pyi
@@ -80,7 +80,7 @@ Traceback = NamedTuple(
 _FrameRecord = Tuple[FrameType, str, int, str, List[str], int]
 
 def getouterframes(frame: FrameType, context: int = ...) -> List[FrameType]: ...
-def getframeinfo(frame: Union[FrameType, TracebackType] , context: int = ...) -> Traceback: ...
+def getframeinfo(frame: Union[FrameType, TracebackType], context: int = ...) -> Traceback: ...
 def getinnerframes(traceback: TracebackType, context: int = ...) -> List[FrameType]: ...
 
 def currentframe() -> FrameType: ...
diff --git a/stdlib/2/posix.pyi b/stdlib/2/posix.pyi
index 6c63864f0..f8feb0360 100644
--- a/stdlib/2/posix.pyi
+++ b/stdlib/2/posix.pyi
@@ -7,50 +7,50 @@ environ = ...  # type: Dict[str, str]
 pathconf_names = ...  # type: Dict[str, int]
 sysconf_names = ...  # type: Dict[str, int]
 
-EX_CANTCREAT= ...  # type: int
-EX_CONFIG= ...  # type: int
-EX_DATAERR= ...  # type: int
-EX_IOERR= ...  # type: int
-EX_NOHOST= ...  # type: int
-EX_NOINPUT= ...  # type: int
-EX_NOPERM= ...  # type: int
-EX_NOUSER= ...  # type: int
-EX_OK= ...  # type: int
-EX_OSERR= ...  # type: int
-EX_OSFILE= ...  # type: int
-EX_PROTOCOL= ...  # type: int
-EX_SOFTWARE= ...  # type: int
-EX_TEMPFAIL= ...  # type: int
-EX_UNAVAILABLE= ...  # type: int
-EX_USAGE= ...  # type: int
-F_OK= ...  # type: int
-NGROUPS_MAX= ...  # type: int
-O_APPEND= ...  # type: int
-O_ASYNC= ...  # type: int
-O_CREAT= ...  # type: int
-O_DIRECT= ...  # type: int
-O_DIRECTORY= ...  # type: int
-O_DSYNC= ...  # type: int
-O_EXCL= ...  # type: int
-O_LARGEFILE= ...  # type: int
-O_NDELAY= ...  # type: int
-O_NOATIME= ...  # type: int
-O_NOCTTY= ...  # type: int
-O_NOFOLLOW= ...  # type: int
-O_NONBLOCK= ...  # type: int
-O_RDONLY= ...  # type: int
-O_RDWR= ...  # type: int
-O_RSYNC= ...  # type: int
-O_SYNC= ...  # type: int
-O_TRUNC= ...  # type: int
-O_WRONLY= ...  # type: int
-R_OK= ...  # type: int
-TMP_MAX= ...  # type: int
-WCONTINUED= ...  # type: int
-WNOHANG= ...  # type: int
-WUNTRACED= ...  # type: int
-W_OK= ...  # type: int
-X_OK= ...  # type: int
+EX_CANTCREAT = ...  # type: int
+EX_CONFIG = ...  # type: int
+EX_DATAERR = ...  # type: int
+EX_IOERR = ...  # type: int
+EX_NOHOST = ...  # type: int
+EX_NOINPUT = ...  # type: int
+EX_NOPERM = ...  # type: int
+EX_NOUSER = ...  # type: int
+EX_OK = ...  # type: int
+EX_OSERR = ...  # type: int
+EX_OSFILE = ...  # type: int
+EX_PROTOCOL = ...  # type: int
+EX_SOFTWARE = ...  # type: int
+EX_TEMPFAIL = ...  # type: int
+EX_UNAVAILABLE = ...  # type: int
+EX_USAGE = ...  # type: int
+F_OK = ...  # type: int
+NGROUPS_MAX = ...  # type: int
+O_APPEND = ...  # type: int
+O_ASYNC = ...  # type: int
+O_CREAT = ...  # type: int
+O_DIRECT = ...  # type: int
+O_DIRECTORY = ...  # type: int
+O_DSYNC = ...  # type: int
+O_EXCL = ...  # type: int
+O_LARGEFILE = ...  # type: int
+O_NDELAY = ...  # type: int
+O_NOATIME = ...  # type: int
+O_NOCTTY = ...  # type: int
+O_NOFOLLOW = ...  # type: int
+O_NONBLOCK = ...  # type: int
+O_RDONLY = ...  # type: int
+O_RDWR = ...  # type: int
+O_RSYNC = ...  # type: int
+O_SYNC = ...  # type: int
+O_TRUNC = ...  # type: int
+O_WRONLY = ...  # type: int
+R_OK = ...  # type: int
+TMP_MAX = ...  # type: int
+WCONTINUED = ...  # type: int
+WNOHANG = ...  # type: int
+WUNTRACED = ...  # type: int
+W_OK = ...  # type: int
+X_OK = ...  # type: int
 
 def WCOREDUMP(status: int) -> bool: ...
 def WEXITSTATUS(status: int) -> bool: ...
diff --git a/stdlib/2/resource.pyi b/stdlib/2/resource.pyi
index c4e9cdda4..92654a9c5 100644
--- a/stdlib/2/resource.pyi
+++ b/stdlib/2/resource.pyi
@@ -14,7 +14,7 @@ RLIMIT_STACK = ...  # type: int
 RLIMIT_RSS = ...  # type: int
 RLIMIT_NPROC = ...  # type: int
 RLIMIT_NOFILE = ...  # type: int
-RLIMIT_OFILE= ...  # type: int
+RLIMIT_OFILE = ...  # type: int
 RLIMIT_MEMLOCK = ...  # type: int
 RLIMIT_VMEM = ...  # type: int
 RLIMIT_AS = ...  # type: int
diff --git a/stdlib/2/sqlite3/dbapi2.pyi b/stdlib/2/sqlite3/dbapi2.pyi
index 59bf7be95..7a6dcf18e 100644
--- a/stdlib/2/sqlite3/dbapi2.pyi
+++ b/stdlib/2/sqlite3/dbapi2.pyi
@@ -67,7 +67,7 @@ version = ...  # type: str
 def adapt(obj, protocol, alternate): ...
 def complete_statement(sql: str) -> bool: ...
 def connect(database: Union[bytes, unicode],
-            timeout: float = ... ,
+            timeout: float = ...,
             detect_types: int = ...,
             isolation_level: Union[str, None] = ...,
             check_same_thread: bool = ...,
diff --git a/stdlib/2/types.pyi b/stdlib/2/types.pyi
index f1e288b50..2f3b93549 100644
--- a/stdlib/2/types.pyi
+++ b/stdlib/2/types.pyi
@@ -59,8 +59,8 @@ class CodeType:
     co_lnotab = ...  # type: str
     co_name = ...  # type: str
     co_names = ...  # type: Tuple[str, ...]
-    co_nlocals= ...  # type: int
-    co_stacksize= ...  # type: int
+    co_nlocals = ...  # type: int
+    co_stacksize = ...  # type: int
     co_varnames = ...  # type: Tuple[str, ...]
 
 class GeneratorType:
diff --git a/stdlib/2/urllib2.pyi b/stdlib/2/urllib2.pyi
index 98e2d9c61..fa92080b3 100644
--- a/stdlib/2/urllib2.pyi
+++ b/stdlib/2/urllib2.pyi
@@ -16,7 +16,7 @@ class Request(object):
     headers = ...  # type: Dict[str, str]
     unverifiable = ...  # type: bool
     type = ...
-    origin_req_host= ...
+    origin_req_host = ...
     unredirected_hdrs = ...
 
     def __init__(self, url: str, data: str = None, headers: Dict[str, str] = ...,
diff --git a/stdlib/3.4/_stat.pyi b/stdlib/3.4/_stat.pyi
index b68e17679..867321a49 100644
--- a/stdlib/3.4/_stat.pyi
+++ b/stdlib/3.4/_stat.pyi
@@ -59,7 +59,7 @@ def S_ISBLK(mode: int) -> bool: ...
 def S_ISCHR(mode: int) -> bool: ...
 def S_ISDIR(mode: int) -> bool: ...
 def S_ISDOOR(mode: int) -> bool: ...
-def S_ISFIFO(mode: int ) -> bool: ...
+def S_ISFIFO(mode: int) -> bool: ...
 def S_ISLNK(mode: int) -> bool: ...
 def S_ISPORT(mode: int) -> bool: ...
 def S_ISREG(mode: int) -> bool: ...
diff --git a/stdlib/3/dis.pyi b/stdlib/3/dis.pyi
index 424c0bf72..7ce2e9f25 100644
--- a/stdlib/3/dis.pyi
+++ b/stdlib/3/dis.pyi
@@ -1,7 +1,7 @@
 from typing import List, Union, Iterator, Tuple, Optional, Any, IO, NamedTuple
 
 from opcode import (hasconst, hasname, hasjrel, hasjabs, haslocal, hascompare,
-                    hasfree, hasnargs, cmp_op, opname , opmap , HAVE_ARGUMENT,
+                    hasfree, hasnargs, cmp_op, opname, opmap, HAVE_ARGUMENT,
                     EXTENDED_ARG, stack_effect)
 
 import types
diff --git a/stdlib/3/gettext.pyi b/stdlib/3/gettext.pyi
index fef481a22..04bf34a8a 100644
--- a/stdlib/3/gettext.pyi
+++ b/stdlib/3/gettext.pyi
@@ -24,7 +24,7 @@ def find(domain: str, localedir: str = ..., languages: List[str] = ...,
 
 def translation(domain: str, localedir: str = ..., languages: List[str] = ...,
                 class_: Callable[[IO[str]], NullTranslations] = ...,
-                fallback: bool =... , codeset: Any = ...) -> NullTranslations: ...
+                fallback: bool =..., codeset: Any = ...) -> NullTranslations: ...
 
 def install(domain: str, localedir: str = ..., codeset: Any = ...,
             names: List[str] = ...): ...
diff --git a/stdlib/3/sqlite3/dbapi2.pyi b/stdlib/3/sqlite3/dbapi2.pyi
index 106b27ddc..a55a19cac 100644
--- a/stdlib/3/sqlite3/dbapi2.pyi
+++ b/stdlib/3/sqlite3/dbapi2.pyi
@@ -67,7 +67,7 @@ version = ...  # type: str
 def adapt(obj, protocol, alternate): ...
 def complete_statement(sql: str) -> bool: ...
 def connect(database: Union[bytes, AnyStr],
-            timeout: float = ... ,
+            timeout: float = ...,
             detect_types: int = ...,
             isolation_level: Union[str, None] = ...,
             check_same_thread: bool = ...,